THYROID NODULE-OVERVIEW

SUMMARY

1. 76% of the population have incidentally discovered nodules, 5% of these are malignant.
2. Virtually all hot + cystic nodules are benign.
3. Never biopsy a hot nodule ⟹ histology masquarades as follicular thyroid CA ⟹ unnecessary surgery.
4. Cold nodules in Grave's disease may still be malignant: investigate.
5. Cold nodules in MNG have malignant potential: investigate.
6. All palpable nodules should be viewed with US.

7. 5% of children receiving neck radiation go on to develop papillary thyroid CA, colloid adenomas.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].