TBI-MEMORY (PHARMACOLOGIC) MGM

SUMMARY

EFFECTIVE
1. Donepezil likely improves memory following TBI (level 1b).2. Pramiracetam (level 2) & physostigmine (level 1b) may improve memory in men with TBI.

INEFFECTIVE
1. Methylphenidate likely does not improve memory or learning following an ABI.
2. Sertraline has not been shown to improve learning, or memory within the first 12 months.

3. Amantadine is not effective for improving learning and memory deficits.
4. Rivastigmine is not effective in treating memory deficits post ABI.

5. Growth hormone replacement likely does not improve learning and memory.
6. Huperzine A may not improve memory following TBI.

Ref: Marshall S, Harnett A, Welch-West P, Ferri C, Janzen S, Togher L, Teasell R. (2021). Rehabilitation of Learning and Memory Deficits Post Acquired Brain Injury. In Teasell R, Cullen N, Marshall S, Bayley M, Harnett A editors. Evidence-Based Review of Moderate to Severe Acquired Brain Injury. Version 14.0: p1-98.

Reference(s)

Cifu, D.X. (2020). Braddom’s physical medicine and rehabilitation. Elsevier. Get it on Amazon.
Cuccurullo, S. (2019). Physical medicine and rehabilitation board review. New York: Demosmedical. Get it on Amazon.
O’Young, B., Young, M.A. and Stiens, S.A. (2008). Physical Medicine and Rehabilitation Secrets. Mosby. Get it on Amazon.