TBI-ATYPICAL ANTIPSYCHOTICS COMMON SIDE EFFECTS

SUMMARY

ANTI-CHOLINERGIC
1. Sedation
2. Agitation

METABOLIC
3. Hyperglycemia and development of diabetes
4. Weight gain (more so with clozapine and olanzapine)
5. Hyperlipidemia (more so with clozapine, olanzapine, and quetiapine)

CARDIAC
6. QT prolongation

OTHER
7. Stroke: only studied with risperidone; demented elderly patients treated with risperidone experienced more TIAs and strokes than placebo-treated patients
8. Affect D₂ receptors less, hence less likely to cause motor SE such as tardive dyskinesia, PD, dystonia & akathesia
9. All antipsychotics can potentially cause neuroleptic malignant syndrome: fever, rigidity, leucocytosis

Reference(s)

Cifu, D.X. (2020). Braddom’s physical medicine and rehabilitation. Elsevier. Get it on Amazon.
Cuccurullo, S. (2019). Physical medicine and rehabilitation board review. New York: Demosmedical. Get it on Amazon.
O’Young, B., Young, M.A. and Stiens, S.A. (2008). Physical Medicine and Rehabilitation Secrets. Mosby. Get it on Amazon.