STROKE-tPA EXCLUSION CRITERIA (RELATIVE CONTRAINDICATIONS)

SUMMARY

1. Severe neurologic impairment with NIHSS score > 22.2

2. Age < 18 years or > 80 years

3. Malignant cerebral infarction

4. Hx of major surgery within 14 days

5. Hx of significant GIT hemorrhage within 21 days

6. Hx of stroke or TBI within 3 months

7. Hx of recent MI within 30 days

8. Advanced, terminal disease (e.g. cancer)

9. Pregnancy is not an absolute contraindication

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].