SPASTICITY-DIAZEPAM

SUMMARY

1. Facilitates GABA's effect on GABA_A receptors throughout the neuroaxis resulting in membrane hyperpolarization & pre-synaptic inhibition.

2. Dosage: 4-60mg/day.

3. Demonstrated efficacy in SCI and MS spasticity.

4. Adverse effects: sedation, memory impairment, decreased REM sleep.

5. Not suitable in TBI patients due to adverse effects on memory & attention.

6. Can have very long half-life due to active metabolites, may cause withdrawal symptoms if not tapered.

7. Overdose treated with Flumazenil.

Reference(s)

Cifu, D.X. (2020). Braddom’s physical medicine and rehabilitation. Elsevier. Get it on Amazon.
Cuccurullo, S. (2019). Physical medicine and rehabilitation board review. New York: Demosmedical. Get it on Amazon.
O’Young, B., Young, M.A. and Stiens, S.A. (2008). Physical Medicine and Rehabilitation Secrets. Mosby. Get it on Amazon.