SPASTICITY-BACLOFEN

SUMMARY

1. Oral GABA-mimetic agent that acts as a GABA agonist at GABA_B receptors.

2. Pre-synaptic terminal: decreases Ca²⁺ influx & decreases Ach release. Post-synaptic terminal: increases K⁺ egress & increases membrane depolarization threshold.

3. Careful dose titration period with a usual maximal recommended dose of 100-150 mg/day.

4. Baclofen is especially effective in reducing flexor spasms (Shahani & Young 1974; Duncan et al. 1976; Gracies et al. 1997).

5. Management of choice in generalized, mild to moderate spasticity & when Botox injection is unavailable (prohibitive cost, lack of technical expertise).

Reference(s)

Cifu, D.X. (2020). Braddom’s physical medicine and rehabilitation. Elsevier. Get it on Amazon.
Cuccurullo, S. (2019). Physical medicine and rehabilitation board review. New York: Demosmedical. Get it on Amazon.
O’Young, B., Young, M.A. and Stiens, S.A. (2008). Physical Medicine and Rehabilitation Secrets. Mosby. Get it on Amazon.