SERONEGATIVE ARTHRITIS-SPONDYLOARTHRITIS

SUMMARY

1. Seronegative spondyloarthritides are a group of inflammatory spinal arthritides that are rheumatoid-factor and ANA-negative.

2. Subtypes: radiographic (sacroilitis on X-ray, AS, peripheral spondylitis); non-radiographic (either MRI evidence of sacroilitis or HL-B27 positive with clinical features)

3. These arthritides have been categorized as "axial" or "peripheral". Include AS, reactive arthritis, psoriatic arthritis, IBD-associated arthropathy.

4. Predilection for the spine, SI joints, and entheses (where the tendons, ligaments, and joint capsules attach).

5. Asymmetric, large-joint oligoarthritis, usually of the lower extremities.

6. Extra-articular manifestations.

7. Variable association with HLA-B27.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].