SEIZURES-PHENYTOIN

SUMMARY

1. Effective and well-tried, but no longer 1st line for generalized or partial epilepsy.

2. Toxicity: nystagmus, diplopia, tremor, dysarthria, ataxia.

3. SEs: decreased intellect, depression, coarse facial features, acne, gum hypertrophy, polyneuropathy, blood dyscrasias.

4. Increased clearance: OCP use, pregnancy.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].