RENIN ANGIOTENSIN SYSTEM-TISSUE SYSTEM
From NeuroRehab.wiki
SUMMARY
1. Independent of circulating RAS.
2. Intrarenal RAS: most important tissue RAS.
3. Angiotensin II in renal interstitial fluid is approximately 1000x higher than in the systemic system.
4. Very sensitive to sodium intake.
5. Causes vasoconstriction and anti-natriuresis.
Reference(s)
Barrett, K.E., Barman, S.M., Brooks, H.L., X, J. and Ganong, W.F. (2019). Ganong’s review of medical physiology. 26th ed. New York: Mcgraw-Hill Education
