RENIN ANGIOTENSIN SYSTEM-RENIN
From NeuroRehab.wiki
SUMMARY
1. Stimuli: hypotension, volume depletion, increased sympathetic activity.
2. Receptors detecting change in ECF volume: baroreceptors or stretch receptors in the wall of the afferent arteriole, cardiac and arterial receptors, cells of macula densa in early distal tubule (stimulated by decrease in chloride).
3. Acute: renin released from granules.
4. Chronic stimuli: increased synthesis of pro-renin.
5. Renin levels increase with ACE-I and A-II receptor blockers.
Reference(s)
Barrett, K.E., Barman, S.M., Brooks, H.L., X, J. and Ganong, W.F. (2019). Ganong’s review of medical physiology. 26th ed. New York: Mcgraw-Hill Education
