RENAL TUBULAR ACIDOSIS (RTA)-TYPE 1 MANAGEMENT

SUMMARY

Hypokalaemia is reversed with alkali therapy(sodium bicarbonate):

1. Increase sodium bicarbonate to distal nephron increases urine pH => more hydrogen is
secreted before saturating gradient occurs

2. Sodium load expands ECF volume => reduces drive for sodium reabsorption and reduce aldosterone secretion.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].