POLYARTERITIS NODOSA (PAN)-CLINICAL & MANAGEMENT

SUMMARY

1. Patients present(s) with anorexia, weight loss, fevers, malaise, arthralgias, mononeuritis multiplex, CNS symptoms, abdominal symptoms, and lower extremity rashes (palpable purpura, livedo reticularis, nodules, and bullae/vesicles).

2. Renal involvement usually presents as HTN, mild proteinuria, and hematuria without red cell casts.

3. Inx: angiogram which reveals characteristic aneurysms, ANCA negative, bx involved sites.

4. Tx involves management of chronic HBV, prednisone +/- cyclophosphamide.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].