PATHOLOGY

SUMMARY

1. Artherosclerosis is a chronic inflammatory response of the arterial wall.

2. The initial injury to the endothelium causes endothelial dysfunction.

3. Monocytes migrate into the intima, transform into foam cells; platelets activate; smooth muscle cells proliferate.

4. Lipids accumulate in the SM cells & foam cells.

5. Forms a fibromuscular plaque: fibromuscular layer with cholesterol core.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].