NEUROPATHY-PARAPROTEINAEMIA

SUMMARY

1. Monoclonal gammopathies are more common in patients with neuropathy than the general population.

2. IgM more strongly assoc. with peripheral neuropathy than IgG or IgA.

3. Anti-MAG (myelin assoc. glycoprotein) Ab assoc. with distal demyelinating sensory neuropathy.

4. Anti-Gd1b Ab assoc. with sensory ataxia and cryoglobulinaemia which in turn causes vasculitic-type and painful sensory neuropathies.

5. IgG paraproteins assoc. with myeloma, amyloidosis, POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein & skin changes).

6. Serum immunofixation electrophoresis more sensitive than serum protein electrophoresis.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].