NCS-CIP & CIM

SUMMARY

1. Critical Illness Polyneuropathy (CIP) and/or Critical Illness Myopathy (CIM) are common causes of weakness and sensory deficits in patients admitted to the ICU.

PATHOLOGY
2. CIP: inactivation of sodium channels leading to electrical inactivity, axonal degeneration. Common complication of severe sepsis and is thought to be a neurologic manifestation of SIRS.
3. CIM: muscle membrane inexcitability, myosin loss, type 2 myofiber atrophy and muscle necrosis.

Reference(s)

Lacomis, D., 2021. Neuromuscular weakness related to critical illness. [online] Uptodate.com. Available at: illness polyneuropathy in ICU,caused by reduced sodium permeability. UpToDate.com [Accessed 20 March 2021].

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].