MYASTHENIA GRAVIS-TYPES

SUMMARY

1. Generalized MG presents as episodic weakness with repetitive movements, worse at end of day.

2. Muscle fatigue: worsening weakness with repetitive muscle stimulation suggests diagnosis.

3. Muscles of facial expression, mastication, swallowing, and speech are affected in 80% of patients at some time in the illness.

3. Ocular MG presents as weakness localized to the eyes (lids and extraocular muscles).

4. Differentiate from other forms of ptosis: demonstrate fatigable ptosis (worsening of ptosis on 30 seconds of sustained up gaze).

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].