MND-MOTOR NEURON DISEASE

SUMMARY

1. Can be UMN (corticobulbar & corticospinal), LMN (bulbar & spinal) or mixed.

2. Etiology: infection, inflammation, cytotoxic, genetic. Direct infection and injury to anterior horn cells are seen as a result of the polio virus.

3. Group of neurodegenerative disorders including:
- Amyotrophic lateral sclerosis (ALS), most common
- Primary lateral sclerosis (PLS)
- Progressive muscular atrophy (PMA)
- Progressive bulbar palsy (PBP)

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].