MINIMAL CHANGE DISEASE (MCD)

SUMMARY

1. Nephrotic-range proteinuria (nephrotic syndrome, renal presentation)
2. More common in children
3. Causes: NSAIDs, lymphoma, atopy
4. Complications: risk of infections and DVT
5. Histopath: loss of foot processes, oval fat bodies
6. Management: steroids
7. Generally very good prognosis

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].