MHC-HUMAN LEUKOCYTE ANTIGENS (HLA)

SUMMARY

1. Class I includes the HLA-A, HLA-8, and HLA-C antigens, which interact with CD8 or T suppressor cells.

2. Class II includes the HLA-D antigens; e.g. DR2, DR3, and DR4, which interact with CD4 or T helper cells.

3. Note: An easy way to remember this relationship is that both form a product of 8. MHC-1 * CD8 = 8, while MHC-2 * CD4= 8.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].