LOC-OVER SEDATION MANAGEMENT

From NeuroRehab.wiki

SUMMARY

1. Most common cause of LOC is over-sedation
2. Most commonly due to opioid toxicity, managed with Naloxone/Flumazenil
3. Note that IM Naloxone lasts longer (approx. 2 hrs)! Can be used if IV Naloxone infusion is not an option
4. Naloxone infusion: 1 mg to 100 mL, 10-40 mL/hr
5. Flumazenil infusion: 0.1-0.5 mg, 10-40mL/hr

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