INTRACELLULAR CALCIUM-BINDING PROTEINS

SUMMARY

1. Many different Ca-binding proteins: troponin, calmodulin, calbindin.
2. Troponin is involved in skeletal muscle contraction.
3. When calmodulin binds Ca it can activate 5 different kinases.

CALMODULIN KINASES
4. Myosin light-chain kinase: smooth muscle contraction
5. CaMKI and CaMKII: synaptic function
6. CaMKIII: protein synthesis
7. Calcuneurin: phosphatase that inactivetes Ca channels, for T-cell activation

Reference(s)

Barrett, K.E., Barman, S.M., Brooks, H.L., X, J. and Ganong, W.F. (2019). Ganong’s review of medical physiology. 26th ed. New York: Mcgraw-Hill Education