INCLUSION BODY MYOSITIS

SUMMARY

1. Most common inflammatory myopathy in persons > 50 years of age, more common in Caucasian men.

2. Indolent disorder characterized by prominent asymmetric distal weakness (weak handshake), dysphagia (leading to aspiration).

3. Risk factors: antimalarials, glucocorticoids, colchicine, statins, cocaine and alcohol use.

4. CK is only mildly elevated, muscle bx is diagnostic.

5. Take patients off the precipitating drugs and give a trial of steroids. Only minimally responsive to treatment.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].