HYPONATREMIA-SIADH CAUSES

SUMMARY

1. Ectopic secretion of ADH: small cell lung carcinoma (most common tumor). Secretes high levels of ADH leading to high urine osmolality.

2. Any CNS disorder can cause SIADH.

3. Drugs: chlorpropamide, carbamazepine, SSRI, chemotherapy drugs, immunosuppression, ciprofloxacin, amiodarone, ecstasy.

4. Any recent surgery.

5. Hypersecretion of ADH: mediated via pain afferents.

6. Pulmonary disease.

7. Hormone def: hypopituitarism and low TSH.

8. Idiopathic: normally due to occult tumor or giant cell arteritis.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].