HORMONES-GLUCOCORTICOIDS

SUMMARY

CORTISOL

1. Stimulate lipolysis, mobilises fat deposits.
2. Release of amino acids from muscles, protein catabolism.
3. Gluconeogenesis from liver, increases serum glucose.
4. Inhibits all stages of the inflammatory process via effect on T cells and their mediators.
5. Decreases bone protein matrix.
6. Excess can stimulate mineralocortocoid + androgen receptors.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].