GLOMERULONEPHRITIS-INFECTION RELATED GN

SUMMARY

1. Previously most in children following strep URT or skin infections “post infectious GN”.

2. Shift in epidemiology, bacteriology and outcomes in IRGN, incidence decreased over past 5 decades.

3. Dx: kidney biopsy, in most with preceding or concurrent infection with low C3.

4. DDx: SLE, Cryoglobulinaemia, C3 glomerulopathy, IgA, ANCA.

5. Risk factors: DM, male (1.4:1 to 3:1 Male:Female), immunocompromised background (seen in 49% in one study), alcoholism, malignancy, malnutrition, synthetic heart valve, IVDU, AIDS, TB.

6. Strep infections are more common in developing countries, whereas Staph infection are common in developed countries.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].