GLOMERULONEPHRITIS-IMMUNE COMPLEX GN

SUMMARY

1. Characterised by glomerular deposits of polyclonal Ig on immunofluorescence or immunohistochemistry.

2. Complement often co-deposited with the Ig.

3. Pattern of glomerular injury variable, there may be no lesion by light-microscopy, mesangial proliferation, endocapillary proliferation, exudative, membranoproliferative, necrotizing and crescentic or a combination of these patterns.

4. Includes: IgA Nephropathy, Lupus Nephritis, Infection Related Glomerulonephritis, Fibrillary Glomerulonephritis, Autoimmune diseases (other than SLE).

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].