GLOMERULONEPHRITIS-CRYSTAL STORING HISTIOCYTOSIS

SUMMARY

1. Numerous enlarged histiocytes containing MIg are noted in the glomeruli and/or interstitium.

2. LM: glomerular capillary loops infiltrated with histiocytes, sometimes associated with membranoproliferative features and subendothelial deposits.

3. Deposits: typically κ light chain restricted.

4. Presentation: proteinuria with or without NS & renal insufficiency.

5. Most frequently seen in setting of Multiple Myeloma and lymphoproliferative disorders. Only rarely seen in MGRS.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].