GLOMERULONEPHRITIS-CRYOGLOBULINAEMIC GN

SUMMARY

1. Cryglobulinaemic GN associated with MIg shows a membranoproliferative pattern with abundant infiltrating macrophages and intraluminal periodic acid-schiff (PAS) positive deposits on LM.

2. Deposits: most often IgM, less often IgG. Co-deposition of C1q and C3.

PRESENTATION
3. Type 1: features of TMA common (Raynaud phenomenon, livedo reticularis, acrocyanosis.

4. Type 2 and 3: present with Meltzer Triad (weakness, arthralgias and purpura, less commonly present with peripheral neuropathy). There is RF activity.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].