DIABETES MELLITUS-NEPHROPATHY MANAGEMENT

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SUMMARY

ACE INHIBITORS/ANGIOTENSIN RECEPTOR BLOCKERS
1. Renoprotection in T2DM offered by ACEi & ARBs was demonstrated in RENAAL & IDNT studies.
2. These work by reducing intraglomerular pressure, by reducing efferent arteriolar tone.

SGLT2 INHIBITION
3. The CREDENCE study delay in progress in patients with established diabetic nephropathy who were treated with Canagliflozin[1].


Reference(s)

  1. Perkovic, V., de Zeeuw, D., Mahaffey, K., Fulcher, G., Erondu, N., Shaw, W., Barrett, T., Weidner-Wells, M., Deng, H., Matthews, D. and Neal, B., 2018. Canagliflozin and renal outcomes in type 2 diabetes: results from the CANVAS Program randomised clinical trials. The Lancet Diabetes & Endocrinology, 6(9), pp.691-704.


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