DIABETES MELLITUS-GLITAZONES

SUMMARY

1. Enhance insulin sensitivity and may help preserve some function of pancreatic beta cells.

2. 2 approved agents: rosiglitazone and pioglitazone.

3. Favorable effects: modest reduction in blood pressure, increased HDL, and decreased TGs.

4. Adverse effects: hepatotoxicity, luid retention and increased risk of exacerbating stable CHF, weight gain, increased risk of fractures.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].