DEMENTIA-ANTIPSYCHOTICS

SUMMARY

1. Risperidone: 0.25 mg BD orally initially, increase by 0.25 mg every 2 days. Max dose 2 mg daily.

2. Olanzapine: 2.5 mg DAILY orally initially, increase by 2.5 mg every 2 days. Max dose 10 mg daily.

3. Quetiapine: 12.5 mg NOCTE orally initially. Max dose 75 mg daily.

NB: 2018 Cochrane review showed that discontinuation may make little/no difference to overall Behavioural & Psychological Symptoms of Dementia (BPSD), these may be successfully discontinued in adults ≥ 65 yrs.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].