CARDIAC OUTPUT (CO)-SOME INOTROPES

SUMMARY

1. Catecholamines ⟹ via beta1 adrenoceptors ⟹ increase intracellular cAMP.

2. Xanthines (caffine, theophylline) ⟹ via inhibition of breakdown of cAMP ⟹ increase intracelular cAMP.

3. Digitalis ⟹ effect the Na/K-ATPase ⟹ decrease calcium removal from the cytosol.

Reference(s)

Barrett, K.E., Barman, S.M., Brooks, H.L., X, J. and Ganong, W.F. (2019). Ganong’s review of medical physiology. 26th ed. New York: Mcgraw-Hill Education