CANCER REHABILITATION-LYTIC VS SCLEROTIC METS

SUMMARY

Metastatic bone lesions can present as osteolytic (lytic lesions) or osteoblastic (sclerotic lesions):

LYTIC LESIONS
1. Lytic lesions decrease the strength and stiffness of the bone (more prone to fracture); while blastic lesions decrease stiffness but do not change the strength of bone.
2. Common in myeloma, lung, kidney, thyroid, malignant lymphomas, breast.
3. Median survival rates for these cancers with metastatic disease: lungs & kidney, 6 mths.

BLASTIC LESIONS
4. Prostate CA, median survival 40 mths.
5. 60% of breast CA presents as osteoblastic lesions. Median survival in breast CA with only skeletal metastases is 24 mths.

Reference(s)

Cifu, D.X. (2020). Braddom’s physical medicine and rehabilitation. Elsevier. Get it on Amazon.
Cuccurullo, S. (2019). Physical medicine and rehabilitation board review. New York: Demosmedical. Get it on Amazon.
O’Young, B., Young, M.A. and Stiens, S.A. (2008). Physical Medicine and Rehabilitation Secrets. Mosby. Get it on Amazon.