CALCIUM-HYPOCALCEMIA CAUSES

SUMMARY

Most commonly:
1. Vitamin D deficiency
2. CKD: secondary hyperpara­thyroidism due to decreased renal conversion of activated Vit D.
3. Severe pancreatitis
4. Rhabdomyolysis
5. Hypomagnesemia (always check magnesium level!)
6. Hyperphosphatemia: in renal excretion of phosphorus in which calcium chelates with the phosphorus.

Less commonly:
7. Hungry bone syndrome following parathyroidectomy
8. Hypoparathyroidism
9. Pseudohypoparathyroidism
10. Citrate: used as an anticoagulant in whole blood. It chelates calcium in the serum, causing hypocalcemia after massive whole blood transfusions.

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].