AUTOREGULATION-KININS
From NeuroRehab.wiki
SUMMARY
1. Two types: bradykinin & kallidin.
2. Actions resemble those of histamine: visceral smooth muscle contraction, vascular smooth muscle relaxation (through the action of NO), vasodilation, increased capillary permeability, attracts leukocytes.
3. Both formed by high molecular weight (high-MW) and low-MW kininogen, after being cleaved by proteases called kallikreins.
4. Formed in sweat glands, salivary glands, exocrine pancreas.
5. Both kinins are inactivated by kininase I & II.
Reference(s)
Barrett, K.E., Barman, S.M., Brooks, H.L., X, J. and Ganong, W.F. (2019). Ganong’s review of medical physiology. 26th ed. New York: Mcgraw-Hill Education
