AUTOREGULATION-ENDOTHELIN

From NeuroRehab.wiki

SUMMARY

1. One of the most potent vascoconstrictors known to man, 3 types: ET-1, ET-2, ET-3.

2. Not stored in vesicles but produced by endothelial cells, made fresh every time via transcription (half-life <1 min).

3. Release triggered by: stretched vascular wall, GF, HDL, oxidised LDL, Angiotensin-II, hypoxia.

4. Release inhibited by (vasodilators): NO, ANP, PGI-2.


Reference(s)

Barrett, K.E., Barman, S.M., Brooks, H.L., X, J. and Ganong, W.F. (2019). Ganong’s review of medical physiology. 26th ed. New York: Mcgraw-Hill Education