ARRHYTHMIAS-DRUG SIDE EFFECTS
SUMMARY
1. Class 1: prolongs QT-interval and increases QRS interval.Quinidine, disopyramide can lead to torsades de pointes. Procaainamide causes drug-induced lupus.2. Class 2: beta-blockers can cause hypotension, decrease libido and cause impotence.
3. Class 3: all of these prolong QT-interval, increase QRS interval and lead to torsades de pointes. Amiodarone: because of its high iodine content, the most toxic, SE: corneal deposits, gray skin, hypoe/hypothyroidism, pulmonary fibrosis.
4. Digitalis toxicity: occurs in patients with low K+, low Mg+2, low low pO2, low renal function. Determined by changes in ECG, not in blood levels.
Reference(s)
Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].
