PAIN-NSAID MECHANISMS

SUMMARY

1. COX-1: responsible for homeostatic functions such as platelet aggregation & maintenance of UGIT mucosal integrity by producing protective prostaglandins.

2. COX-2: inducible cytokine that produces inflammation & pain.

3. Conventional (non-specific) NSAIDs: first-line treatment for analgesia and the treatment of inflammatory conditions (OA, RA, various musculoskeletal-related conditions).

4. Oral COX-2 inhibitors approved by FDA: celecoxib, meloxicam spares COX-1 at selected doses.

Reference(s)

Cifu, D.X. (2020). Braddom’s physical medicine and rehabilitation. Elsevier. Get it on Amazon.
Cuccurullo, S. (2019). Physical medicine and rehabilitation board review. New York: Demosmedical. Get it on Amazon.
O’Young, B., Young, M.A. and Stiens, S.A. (2008). Physical Medicine and Rehabilitation Secrets. Mosby. Get it on Amazon.