LYMPHEDEMA-ETIOLOGY

SUMMARY

Lymphoedema: primary vs. secondary (majority related to cancer):

PRIMARY
1. Lymphoedema assoc. with syndromes: GJC 2, GATA 2, KIF 11 gene abnormalities
2. Congenital abnormalities: lymphatic dysplasia, Milroy's disease, multi-segment/unisegment disease
3. Other assoc. abnormalities: klippel-Trenauney, Parks-Weber, Proteus
4. Lymphoedema-distichiasis: combination of lymphoedema & double eye lashes

SECONDARY
1. Cancer-related: 68%
2. Trauma/surgical
3. Obesity
4. Dependency
5. Inflammatory

Reference(s)

Cifu, D.X. (2020). Braddom’s physical medicine and rehabilitation. Elsevier. Get it on Amazon.
Cuccurullo, S. (2019). Physical medicine and rehabilitation board review. New York: Demosmedical. Get it on Amazon.
O’Young, B., Young, M.A. and Stiens, S.A. (2008). Physical Medicine and Rehabilitation Secrets. Mosby. Get it on Amazon.