SJOGREN'S SYNDROME-PRESENTATION

SUMMARY

Mucus glands are infiltrated by lymphocytes and plasma cells leading to atrophy and fibrosis.

Presentation:

1. Dry eyes: conjunctivitis, corneal ulcers
2. Dry mouth
3. Chest infection: due to reduced mucus production
4. Kidneys - RTA, nephrogenic DI
5. Genital tract - atrophic vaginitis
6. Pseudolymphoma - lymphadenopathy and splenomegaly which can progress to non-Hodgkin's lymphoma

Reference(s)

Wilkinson, I., Furmedge, D. and Sinharay, R. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press. Get it on Amazon.
Feather, A., Randall, D. and Waterhouse, M. (2020). Kumar And Clark’s Clinical Medicine. 10th ed. S.L.: Elsevier Health Sciences. Get it on Amazon.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].