RENAL TUBULAR ACIDOSIS (RTA)-TYPE 1 MANAGEMENT
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Revision as of 11:48, 31 January 2023 by Dr Appukutty Manickam (talk | contribs) (Imported from text file)
SUMMARY
Hypokalaemia is reversed with alkali therapy(sodium bicarbonate):
1. Increase sodium bicarbonate to distal nephron increases urine pH => more hydrogen is
secreted before saturating gradient occurs
2. Sodium load expands ECF volume => reduces drive for sodium reabsorption and reduce aldosterone secretion.
Reference(s)
Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].
