GLOMERULONEPHRITIS-INFECTION RELATED GN

SUMMARY

1. Previously most in children following strep URT or skin infections “post infectious GN”.

2. Shift in epidemiology, bacteriology and outcomes in IRGN, incidence decreased over past 5 decades.

3. Dx: kidney biopsy, in most with preceding or concurrent infection with low C3.

4. DDx: SLE, Cryoglobulinaemia, C3 glomerulopathy, IgA, ANCA.

5. Risk factors: DM, male (1.4:1 to 3:1 Male:Female), immunocompromised background (seen in 49% in one study), alcoholism, malignancy, malnutrition, synthetic heart valve, IVDU, AIDS, TB.

6. Strep infections are more common in developing countries, whereas Staph infection are common in developed countries.

Reference(s)

Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].