GLOMERULONEPHRITIS-CRYSTAL STORING HISTIOCYTOSIS

SUMMARY

1. Numerous enlarged histiocytes containing MIg are noted in the glomeruli and/or interstitium.

2. LM: glomerular capillary loops infiltrated with histiocytes, sometimes associated with membranoproliferative features and subendothelial deposits.

3. Deposits: typically κ light chain restricted.

4. Presentation: proteinuria with or without NS & renal insufficiency.

5. Most frequently seen in setting of Multiple Myeloma and lymphoproliferative disorders. Only rarely seen in MGRS.

Reference(s)

Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].