GLOMERULONEPHRITIS-CRYOGLOBULINAEMIC GN

SUMMARY

1. Cryglobulinaemic GN associated with MIg shows a membranoproliferative pattern with abundant infiltrating macrophages and intraluminal periodic acid-schiff (PAS) positive deposits on LM.

2. Deposits: most often IgM, less often IgG. Co-deposition of C1q and C3.

PRESENTATION
3. Type 1: features of TMA common (Raynaud phenomenon, livedo reticularis, acrocyanosis.

4. Type 2 and 3: present with Meltzer Triad (weakness, arthralgias and purpura, less commonly present with peripheral neuropathy). There is RF activity.

Reference(s)

Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].