ACID BASE DISORDERS-ACIDOSIS & CALCIUM

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SUMMARY

1. Acidosis decreases the fraction of bound calcium and increases the ionized calcium.

2. Correction of acido­sis prior to correction of hypocalcemia in this setting removes the protective effect of the acidosis, and can precipitate hypocalcemic seizures.


Reference(s)

Wilkinson, I. (2017). Oxford handbook of clinical medicine. Oxford: Oxford University Press.
Hannaman, R. A., Bullock, L., Hatchell, C. A., & Yoffe, M. (2016). Internal medicine review core curriculum, 2017-2018. CO Springs, CO: MedStudy.
Therapeutic Guidelines. Melbourne: Therapeutic Guidelines Limited. https://www.tg.org.au [Accessed 2021].