RENIN ANGIOTENSIN SYSTEM-RENIN

SUMMARY

1. Stimuli: hypotension, volume depletion, increased sympathetic activity.

2. Receptors detecting change in ECF volume: baroreceptors or stretch receptors in the wall of the afferent arteriole, cardiac and arterial receptors, cells of macula densa in early distal tubule (stimulated by decrease in chloride).

3. Acute: renin released from granules.

4. Chronic stimuli: increased synthesis of pro-renin.

5. Renin levels increase with ACE-I and A-II receptor blockers.

Reference(s)

Barrett, K.E., Barman, S.M., Boitano, S., Brooks, H.L., Weitz, M., Brian Patrick Kearns, Ganong, W.F. and Mcgraw-Hill Education (Firm (2016). Ganong’s review of medical physiology. 25th ed. New York: Mcgraw Hill Education.
Hall, J.E. and Hall, M.E. (2020). Guyton And Hall Textbook Of Medical Physiology. 14th ed. S.L.: Elsevier - Health Science.
West, J.B. and Luks, A.M. (2021). West’s Pulmonary Pathophysiology. Lippincott Williams & Wilkins.