AUTOREGULATION-KININS

SUMMARY

1. Two types: bradykinin & kallidin.

2. Actions resemble those of histamine: visceral smooth muscle contraction, vascular smooth muscle relaxation (through the action of NO), vasodilation, increased capillary permeability, attracts leukocytes.

3. Both formed by high molecular weight (high-MW) and low-MW kininogen, after being cleaved by proteases called kallikreins.

4. Formed in sweat glands, salivary glands, exocrine pancreas.

5. Both kinins are inactivated by kininase I & II.

Reference(s)

Barrett, K.E., Barman, S.M., Boitano, S., Brooks, H.L., Weitz, M., Brian Patrick Kearns, Ganong, W.F. and Mcgraw-Hill Education (Firm (2016). Ganong’s review of medical physiology. 25th ed. New York: Mcgraw Hill Education.
Hall, J.E. and Hall, M.E. (2020). Guyton And Hall Textbook Of Medical Physiology. 14th ed. S.L.: Elsevier - Health Science.
West, J.B. and Luks, A.M. (2021). West’s Pulmonary Pathophysiology. Lippincott Williams & Wilkins.