AUTOREGULATION-ENDOTHELIN

SUMMARY

1. One of the most potent vascoconstrictors known to man, 3 types: ET-1, ET-2, ET-3.

2. Not stored in vesicles but produced by endothelial cells, made fresh every time via transcription (half-life <1 min).

3. Release triggered by: stretched vascular wall, GF, HDL, oxidised LDL, Angiotensin-II, hypoxia.

4. Release inhibited by (vasodilators): NO, ANP, PGI-2.

Reference(s)

Barrett, K.E., Barman, S.M., Boitano, S., Brooks, H.L., Weitz, M., Brian Patrick Kearns, Ganong, W.F. and Mcgraw-Hill Education (Firm (2016). Ganong’s review of medical physiology. 25th ed. New York: Mcgraw Hill Education.
Hall, J.E. and Hall, M.E. (2020). Guyton And Hall Textbook Of Medical Physiology. 14th ed. S.L.: Elsevier - Health Science.
West, J.B. and Luks, A.M. (2021). West’s Pulmonary Pathophysiology. Lippincott Williams & Wilkins.