RENAL-CREATININE

SUMMARY

1. Serum creatinine: from metabolism of creatine in skeletal muscle and dietary meat intake.

2. Very variable and depends on age, sex, body size.

3. Creatinine is freely filtered across the glomeruli and not reabsorbed in the tubules but also secreted by proximal tubules.

4. Glomerular filtration rate (GFR): 180 l/day or 125 ml/min of plasma.

5. GFR cannot be measured directly.

Reference(s)

Barrett, K.E., Barman, S.M., Boitano, S., Brooks, H.L., Weitz, M., Brian Patrick Kearns, Ganong, W.F. and Mcgraw-Hill Education (Firm (2016). Ganong’s review of medical physiology. 25th ed. New York: Mcgraw Hill Education.
Hall, J.E. and Hall, M.E. (2020). Guyton And Hall Textbook Of Medical Physiology. 14th ed. S.L.: Elsevier - Health Science.
West, J.B. and Luks, A.M. (2021). West’s Pulmonary Pathophysiology. Lippincott Williams & Wilkins.