INTRACELLULAR CALCIUM-BINDING PROTEINS

SUMMARY

1. Many different Ca-binding proteins: troponin, calmodulin, calbindin.
2. Troponin is involved in skeletal muscle contraction.
3. When calmodulin binds Ca it can activate 5 different kinases.

CALMODULIN KINASES
4. Myosin light-chain kinase: smooth muscle contraction
5. CaMKI and CaMKII: synaptic function
6. CaMKIII: protein synthesis
7. Calcuneurin: phosphatase that inactivetes Ca channels, for T-cell activation

Reference(s)

Barrett, K.E., Barman, S.M., Boitano, S., Brooks, H.L., Weitz, M., Brian Patrick Kearns, Ganong, W.F. and Mcgraw-Hill Education (Firm (2016). Ganong’s review of medical physiology. 25th ed. New York: Mcgraw Hill Education.
Hall, J.E. and Hall, M.E. (2020). Guyton And Hall Textbook Of Medical Physiology. 14th ed. S.L.: Elsevier - Health Science.
West, J.B. and Luks, A.M. (2021). West’s Pulmonary Pathophysiology. Lippincott Williams & Wilkins.